A kobalt egy sor enzimet képes aktiválni. A cobalamin, vagyis a B12-vitamin alkotóelemeként részt vesz a vörösvértestek, az ideghüvely és a különböző fehérjék felépítésében. A napi igényt a normál étkezés teljes mértékben fedezi. Embereknél még nem tapasztaltak hiányjelenséget.
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